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Details on Person Activated FGFR3 point, translocation and fusion mutants bind FRS2

Class:Id	Reaction:5655262
_displayName	Activated FGFR3 point, translocation and fusion mutants bind FRS2
_doRelease	TRUE
_timestamp	2021-11-21 13:23:12
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655276] gain_of_function of Activated FGFR3 point, translocation and fusion mutants [plasma membrane]
input	[EntityWithAccessionedSequence:170963] FRS2 [plasma membrane] [Homo sapiens] [DefinedSet:9753847] Activated FGFR3 point, translocation and fusion mutants [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling [LiteratureReference:2067711] GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling [LiteratureReference:8852986] Oncogenic FGFR3 gene fusions in bladder cancer [LiteratureReference:8853033] The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma [LiteratureReference:8852972] Identification of targetable FGFR gene fusions in diverse cancers [LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours [LiteratureReference:8852907] Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction [LiteratureReference:8853053] Transforming fusions of FGFR and TACC genes in human glioblastoma
modified	[InstanceEdit:9753846] Rothfels, Karen, 2021-09-15 [InstanceEdit:9758636] Matthews, Lisa, 2021-11-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3 point, translocation and fusion mutants bind FRS2
normalReaction	[Reaction:5654409] Activated FGFR3 binds FRS2 [Homo sapiens]
output	[Complex:5655312] Activated FGFR3 point, translocation and fusion mutants:FRS2 [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15 [InstanceEdit:8853855] Grose, Richard P, 2016-01-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679891] R-HSA-5655262.3
summation	[Summation:9753845] After activation, FGFR point and translocation mutants are p...
(hasEvent)	[Pathway:5655332] Signaling by FGFR3 in disease [Homo sapiens]
(replacementInstances)	[_Deleted:5655672] Deletion of instance: 1982073 [_Deleted:9768282] Deletion of instance: 8853310
(updatedInstance)	[_UpdateTracker:9775311] Update Tracker - [Reaction:5655262] Activated FGFR3 point, translocation and fusion mutants bind FRS2 - v79:[addLiteratureReference, add_removeInput, add_removeSummation]
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