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Details on Person Activated FGFR2 mutants:p-FRS2 [plasma membrane]

Class:Id	Complex:5655236
_displayName	Activated FGFR2 mutants:p-FRS2 [plasma membrane]
_timestamp	2015-03-04 04:33:03
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
hasComponent	[EntityWithAccessionedSequence:170959] p-6Y-FRS2 [plasma membrane] [Homo sapiens] [DefinedSet:5654747] Activated FGFR2 mutants [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
name	Activated FGFR2 mutants:p-FRS2
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680450] R-HSA-5655236.1
(diseaseEntity)	[EntityFunctionalStatus:5655327] gain_of_function of Activated FGFR2 mutants:p-FRS2 [plasma membrane] [EntityFunctionalStatus:9632015] gain_of_function of Activated FGFR2 mutants:p-FRS2 [plasma membrane]
(hasComponent)	[Complex:5655330] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [Homo sapiens] [Complex:5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] [Homo sapiens]
(input)	[Reaction:5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 [Homo sapiens] [Reaction:5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens]
(output)	[Reaction:5655268] Activated FGFR2 mutants phosphorylate FRS2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9893432] Update Tracker - [Complex:5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] - v56:[updateContainedComponent] [_UpdateTracker:9900965] Update Tracker - [Complex:5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] - v71:[updateContainedComponent]
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No pathways have been reviewed or authored by Activated FGFR2 mutants:p-FRS2 [plasma membrane] (5655236)