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Details on Person FGFR3-associated PI3K phosphorylates PIP2 to PIP3

Class:Id	Reaction:5654705
_displayName	FGFR3-associated PI3K phosphorylates PIP2 to PIP3
_doRelease	TRUE
_timestamp	2015-03-04 03:48:31
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654711] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654703] Rothfels, Karen, 2014-12-03
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR3-associated PI3K phosphorylates PIP2 to PIP3
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654637] Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679782] R-HSA-5654705.2
summation	[Summation:1384553] Once recruited to the activated receptor, PI3K phosphorylate...
(hasEvent)	[Pathway:5654710] PI-3K cascade:FGFR3 [Homo sapiens]
(normalReaction)	[Reaction:5655289] Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(replacementInstances)	[_Deleted:5655535] Deletion of instance: 1268240
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No pathways have been reviewed or authored by FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (5654705)