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Details on Person CBL ubiquitinates FRS2 and FGFR4

Class:Id	Reaction:5654684
_displayName	CBL ubiquitinates FRS2 and FGFR4
_doRelease	TRUE
_timestamp	2015-03-04 04:01:44
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654682] ubiquitin protein ligase activity of Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643490] ubiquitin protein ligase activity of Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654683] Rothfels, Karen, 2014-12-03
input	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [Complex:5654335] Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl [LiteratureReference:1268103] Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
modified	[InstanceEdit:5655525] Rothfels, Karen, 2014-12-05 [InstanceEdit:5655662] Rothfels, Karen, 2014-12-08 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CBL ubiquitinates FRS2 and FGFR4
output	[Complex:5654363] Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 [Homo sapiens] [Reaction:5654655] Activated FGFR4 phosphorylates PPTN11 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680013] R-HSA-5654684.3
summation	[Summation:191560] Grb2 bound to tyrosine phosphorylated FRS2 forms a ternary c...
(hasEvent)	[Pathway:5654733] Negative regulation of FGFR4 signaling [Homo sapiens]
(replacementInstances)	[_Deleted:5655527] Deletion of instance: 1270444
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No pathways have been reviewed or authored by CBL ubiquitinates FRS2 and FGFR4 (5654684)