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Details on Person p-CBL:GRB2 binds p-FRS2:activated FGFR1

Class:Id	Reaction:5654673
_displayName	p-CBL:GRB2 binds p-FRS2:activated FGFR1
_doRelease	TRUE
_timestamp	2017-03-15 14:15:32
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654675] Rothfels, Karen, 2014-12-03
input	[Complex:5654204] Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] [Homo sapiens] [Complex:182964] p-Y371-CBL:GRB2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
modified	[InstanceEdit:5655524] Rothfels, Karen, 2014-12-05 [InstanceEdit:8981917] Rothfels, Karen, 2017-03-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-CBL:GRB2 binds p-FRS2:activated FGFR1
output	[Complex:5654267] Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654587] Activated FGFR1:p-FRS phosphorylates PPTN11 [Homo sapiens] [Reaction:5654584] Activated FGFR1:p-FRS bind to PPTN11 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680055] R-HSA-5654673.3
summation	[Summation:1268284] The ubiquitin ligase CBL exists in a complex with GRB2 and i...
(hasEvent)	[Pathway:5654726] Negative regulation of FGFR1 signaling [Homo sapiens]
(precedingEvent)	[Reaction:5654672] CBL ubiquitinates FRS2 and FGFR1 [Homo sapiens]
(replacementInstances)	[_Deleted:5655529] Deletion of instance: 1270439
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No pathways have been reviewed or authored by p-CBL:GRB2 binds p-FRS2:activated FGFR1 (5654673)