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Details on Person Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA

Class:Id	Reaction:5654640
_displayName	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
_doRelease	TRUE
_timestamp	2015-03-04 04:02:01
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654639] Rothfels, Karen, 2014-12-03
input	[EntityWithAccessionedSequence:74787] PIK3CA [cytosol] [Homo sapiens] [Complex:5654203] Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
modified	[InstanceEdit:5655602] Rothfels, Karen, 2014-12-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
output	[Complex:5654195] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654637] Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens] [Reaction:5654408] Activated FGFR3 phosphorylates FRS2 [Homo sapiens] [Reaction:177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680019] R-HSA-5654640.2
summation	[Summation:188530] The Src homology 2 (SH2) domain of the phosphatidylinositol ...
(hasEvent)	[Pathway:5654710] PI-3K cascade:FGFR3 [Homo sapiens]
(normalReaction)	[Reaction:5655285] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens]
(precedingEvent)	[Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(replacementInstances)	[_Deleted:5655538] Deletion of instance: 1268262
(updatedInstance)	[_UpdateTracker:9780125] Update Tracker - [Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - v64:[modifyText]
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No pathways have been reviewed or authored by Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (5654640)