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Details on Person Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1

Class:Id	Reaction:5654637
_displayName	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
_doRelease	TRUE
_timestamp	2017-03-15 14:09:03
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654638] Rothfels, Karen, 2014-12-03
input	[Complex:179864] GRB2:GAB1:PIK3R1 [cytosol] [Homo sapiens] [Complex:5654196] Activated FGFR3:p-FRS2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
modified	[InstanceEdit:5655601] Rothfels, Karen, 2014-12-05 [InstanceEdit:8981904] Rothfels, Karen, 2017-03-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
output	[Complex:5654203] Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654408] Activated FGFR3 phosphorylates FRS2 [Homo sapiens] [Reaction:5654409] Activated FGFR3 binds FRS2 [Homo sapiens] [Reaction:177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 [Homo sapiens] [Reaction:177920] Binding of GRB2 to GAB1 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679827] R-HSA-5654637.3
summation	[Summation:1268244] The direct GRB2-binding sites of FRS2 have a major role in a...
(hasEvent)	[Pathway:5654710] PI-3K cascade:FGFR3 [Homo sapiens]
(normalReaction)	[Reaction:5655315] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens]
(precedingEvent)	[Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens]
(replacementInstances)	[_Deleted:5655543] Deletion of instance: 1268245
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No pathways have been reviewed or authored by Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (5654637)