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Details on Person Activated FGFR3 phosphorylates PPTN11

Class:Id	Reaction:5654631
_displayName	Activated FGFR3 phosphorylates PPTN11
_doRelease	TRUE
_timestamp	2015-03-04 04:10:52
authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:5654630] protein tyrosine kinase activity of Activated FGFR3:p-FRS:PTPN11 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5654632] Rothfels, Karen, 2014-12-03
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
input	[Complex:5654310] Activated FGFR3:p-FRS:PTPN11 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling [LiteratureReference:1268085] SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3 phosphorylates PPTN11
output	[Complex:5654312] Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:5654633] Activated FGFR3:p-FRS bind to PPTN11 [Homo sapiens] [Reaction:5654408] Activated FGFR3 phosphorylates FRS2 [Homo sapiens] [Reaction:5654628] Activated FGFR3 phosphorylates FRS3 [Homo sapiens]
releaseDate	2010-03-16
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680175] R-HSA-5654631.2
summation	[Summation:191517] Tyrosine phosphorylation of PPTN11/SHP2 by FGFR kinase is re...
(hasEvent)	[Pathway:5654706] FRS-mediated FGFR3 signaling [Homo sapiens]
(precedingEvent)	[Reaction:5654641] Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 [Homo sapiens] [Reaction:5654730] p-CBL:GRB2 binds p-FRS2:activated FGFR3 [Homo sapiens] [Reaction:8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Homo sapiens]
(replacementInstances)	[_Deleted:5655563] Deletion of instance: 190362
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