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Details on Person Activated FGFR3 phosphorylates FRS3

Class:Id	Reaction:5654628
_displayName	Activated FGFR3 phosphorylates FRS3
_doRelease	TRUE
_timestamp	2015-03-04 04:03:39
authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:5654629] protein tyrosine kinase activity of Activated FGFR3:FRS3 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5654627] Rothfels, Karen, 2014-12-03
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:5654297] Activated FGFR3:FRS3 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:1268094] The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3 phosphorylates FRS3
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:5654303] Activated FGFR3:p-FRS3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654623] Activated FGFR3 binds FRS3 [Homo sapiens] [Reaction:190385] Autocatalytic phosphorylation of FGFR3b [Homo sapiens] [Reaction:190388] Autocatalytic phosphorylation of FGFR3c [Homo sapiens]
releaseDate	2010-03-16
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680047] R-HSA-5654628.2
summation	[Summation:191523] FRS3 (also known as FRS2 beta) is activated through tyrosine...
(hasEvent)	[Pathway:5654706] FRS-mediated FGFR3 signaling [Homo sapiens]
(precedingEvent)	[Reaction:5654416] Activated FGFR3:pFRS binds GRB2:SOS1 [Homo sapiens] [Reaction:5654633] Activated FGFR3:p-FRS bind to PPTN11 [Homo sapiens]
(replacementInstances)	[_Deleted:5655566] Deletion of instance: 191471
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