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Details on Person Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Class:Id	Reaction:5654594
_displayName	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
_doRelease	TRUE
_timestamp	2017-03-10 01:31:08
authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5654593] Rothfels, Karen, 2014-12-03
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
input	[Complex:5654204] Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] [Homo sapiens] [Complex:179864] GRB2:GAB1:PIK3R1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation [LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:1268085] SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells
modified	[InstanceEdit:8981532] Rothfels, Karen, 2017-03-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
output	[Complex:5654185] Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 [Homo sapiens] [Reaction:177920] Binding of GRB2 to GAB1 [Homo sapiens]
releaseDate	2010-03-16
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679943] R-HSA-5654594.3
summation	[Summation:1268184] p-PPTN11 recruits GRB2-GAB1 to the activated receptor.
(hasEvent)	[Pathway:5654689] PI-3K cascade:FGFR1 [Homo sapiens]
(precedingEvent)	[Reaction:5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens]
(replacementInstances)	[_Deleted:5655540] Deletion of instance: 190401
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No pathways have been reviewed or authored by Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (5654594)