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Details on Person Activated FGFR1:p-FRS bind to PPTN11

Class:Id	Reaction:5654584
_displayName	Activated FGFR1:p-FRS bind to PPTN11
_doRelease	TRUE
_timestamp	2015-03-04 04:15:24
authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5654583] Rothfels, Karen, 2014-12-03
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
input	[DefinedSet:5654262] Activated FGFR1:p-FRS [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR1:p-FRS bind to PPTN11
output	[Complex:5654268] Activated FGFR1:p-FRS:PTPN11 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654575] Activated FGFR1 phosphorylates FRS2 [Homo sapiens] [Reaction:5654569] Activated FGFR1 binds FRS2 [Homo sapiens] [Reaction:5654578] Activated FGFR1 phosphorylates FRS3 [Homo sapiens] [Reaction:5654571] Activated FGFR1 binds FRS3 [Homo sapiens]
releaseDate	2010-03-16
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680245] R-HSA-5654584.2
summation	[Summation:1268151] p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.
(hasEvent)	[Pathway:5654693] FRS-mediated FGFR1 signaling [Homo sapiens]
(precedingEvent)	[Reaction:5654587] Activated FGFR1:p-FRS phosphorylates PPTN11 [Homo sapiens]
(replacementInstances)	[_Deleted:5655565] Deletion of instance: 190358
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No pathways have been reviewed or authored by Activated FGFR1:p-FRS bind to PPTN11 (5654584)