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Details on Person Activated FGFR1 binds FRS3

Class:Id	Reaction:5654571
_displayName	Activated FGFR1 binds FRS3
_doRelease	TRUE
_timestamp	2015-03-04 03:58:57
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654570] Rothfels, Karen, 2014-12-03
input	[EntityWithAccessionedSequence:191482] FRS3 [plasma membrane] [Homo sapiens] [DefinedSet:5654170] Activated FGFR1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:182133] FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors [LiteratureReference:532259] Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins [LiteratureReference:1268082] FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts [LiteratureReference:1549554] Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR1 binds FRS3
output	[Complex:5654255] Activated FGFR1:FRS3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:190427] Autocatalytic phosphorylation of FGFR1b [Homo sapiens] [Reaction:190245] FGFR1b binds to FGF [Homo sapiens] [Reaction:190429] Autocatalytic phosphorylation of FGFR1c [Homo sapiens] [Reaction:190256] FGFR1c binds to FGF [Homo sapiens] [Reaction:191062] Autocatalytic phosphorylation of Klotho-bound FGFR1c [Homo sapiens] [Reaction:190268] FGFR1c binds to Klotho-bound FGF23 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679975] R-HSA-5654571.2
summation	[Summation:1268222] FRS3 (also known as FRS2beta) is predominantly expressed in ...
(hasEvent)	[Pathway:5654693] FRS-mediated FGFR1 signaling [Homo sapiens]
(precedingEvent)	[Reaction:5654578] Activated FGFR1 phosphorylates FRS3 [Homo sapiens]
(replacementInstances)	[_Deleted:5655571] Deletion of instance: 1268221
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No pathways have been reviewed or authored by Activated FGFR1 binds FRS3 (5654571)