Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2

Class:Id	Reaction:5654560
_displayName	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
_doRelease	TRUE
_timestamp	2024-07-16 19:49:12
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:1268259] MAP kinase activity of p-T,Y MAPK dimers [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654561] Rothfels, Karen, 2014-12-03
input	[Complex:5654176] Activated FGFR1:FRS2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1268094] The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors [LiteratureReference:1268119] FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway [LiteratureReference:1268116] EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2 [LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
modified	[InstanceEdit:6799072] Rothfels, Karen, 2015-09-21 [InstanceEdit:6799088] Rothfels, Karen, 2015-09-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:5654260] Activated FGFR1:p-8T-FRS2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens] [Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens] [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 [Homo sapiens] [BlackBoxEvent:109863] Dissociation of p-T,Y-MAPK3:MAP2K1 [Homo sapiens] [BlackBoxEvent:9610154] Dissociation of phosphorylated MAP2Ks and MAPKs [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679716] R-HSA-5654560.4
summation	[Summation:1268241] FRS2 has 8 canonical MAPK phosphorylation sites which are ph...
(hasEvent)	[Pathway:5654726] Negative regulation of FGFR1 signaling [Homo sapiens]
(replacementInstances)	[_Deleted:5655531] Deletion of instance: 1270466
[Change default viewing format]

No pathways have been reviewed or authored by Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (5654560)