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Details on Person Ligand-independent phosphorylation of overexpressed FGFR1c
Class:Id Reaction:5654545
_displayName Ligand-independent phosphorylation of overexpressed FGFR1c
_doRelease TRUE
_timestamp 2015-05-07 19:56:00
authored [InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity [CatalystActivity:5654541] protein tyrosine kinase activity of FGFR1c homodimer [plasma membrane]
compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol
created [InstanceEdit:5654543] Rothfels, Karen, 2014-12-03
disease [Disease:1500689] cancer
edited [InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus [EntityFunctionalStatus:5654546] gain_of_function of FGFR1c homodimer [plasma membrane]
input [Complex:190222] FGFR1c homodimer [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric FALSE
literatureReference [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:2054033] Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
modified [InstanceEdit:5691479] Rothfels, Karen, 2015-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name Ligand-independent phosphorylation of overexpressed FGFR1c
output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:1982036] Activated overexpressed FGFR1c homodimer [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate 2012-06-12
reviewed [InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:5680139] R-HSA-5654545.2
summation [Summation:1982064] FGFR1-amplified lung cancer and breast cancer cells show str...
(hasEvent) [Pathway:1839120] Signaling by FGFR1 amplification mutants [Homo sapiens]
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