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Details on Person Ligand-independent phosphorylation of overexpressed FGFR1c

Class:IdReaction:5654545
_displayNameLigand-independent phosphorylation of overexpressed FGFR1c
_doReleaseTRUE
_timestamp2015-05-07 19:56:00
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity[CatalystActivity:5654541] protein tyrosine kinase activity of FGFR1c homodimer [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:5654543] Rothfels, Karen, 2014-12-03
disease[Disease:1500689] cancer
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5654546] gain_of_function of FGFR1c homodimer [plasma membrane]
input[Complex:190222] FGFR1c homodimer [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:2054033] Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
[LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
modified[InstanceEdit:5691479] Rothfels, Karen, 2015-05-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLigand-independent phosphorylation of overexpressed FGFR1c
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:1982036] Activated overexpressed FGFR1c homodimer [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680139] R-HSA-5654545.2
summation[Summation:1982064] FGFR1-amplified lung cancer and breast cancer cells show str...
(hasEvent)[Pathway:1839120] Signaling by FGFR1 amplification mutants [Homo sapiens]
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No pathways have been reviewed or authored by Ligand-independent phosphorylation of overexpressed FGFR1c (5654545)