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Details on Person Ligand-independent dimerization of overexpressed FGFR1c

Class:Id	Reaction:5654544
_displayName	Ligand-independent dimerization of overexpressed FGFR1c
_doRelease	TRUE
_timestamp	2015-05-07 19:55:50
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654543] Rothfels, Karen, 2014-12-03
disease	[Disease:1500689] cancer
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654542] gain_of_function of FGFR1c [plasma membrane]
input	[EntityWithAccessionedSequence:189897] FGFR1c [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:189897] FGFR1c [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:2054033] Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
modified	[InstanceEdit:5691477] Rothfels, Karen, 2015-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of overexpressed FGFR1c
output	[Complex:190222] FGFR1c homodimer [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679830] R-HSA-5654544.2
summation	[Summation:1982064] FGFR1-amplified lung cancer and breast cancer cells show str...
(hasEvent)	[Pathway:1839120] Signaling by FGFR1 amplification mutants [Homo sapiens]
(precedingEvent)	[Reaction:5654545] Ligand-independent phosphorylation of overexpressed FGFR1c [Homo sapiens]
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