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Details on Person KAL1 binds FGFR1c

Class:IdReaction:5654514
_displayNameKAL1 binds FGFR1c
_doReleaseTRUE
_timestamp2016-03-21 15:20:31
authored[InstanceEdit:5653741] Rothfels, Karen, 2014-12-01
compartment[Compartment:876] plasma membrane
created[InstanceEdit:5654516] Rothfels, Karen, 2014-12-03
edited[InstanceEdit:5662959] Rothfels, Karen, 2015-01-14
input[EntityWithAccessionedSequence:189897] FGFR1c [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:5654345] KAL1 [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5654104] Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1
[LiteratureReference:5653998] Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator
[LiteratureReference:5653990] Anosmin-1 underlying the X chromosome-linked Kallmann syndrome is an adhesion molecule that can modulate neurite growth in a cell-type specific manner
[LiteratureReference:5654011] Novel insights in FGFR1 regulation: lessons from Kallmann syndrome
[LiteratureReference:5654100] Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome
[LiteratureReference:5654103] Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes
[LiteratureReference:5654002] Kallmann syndrome
[LiteratureReference:5654007] Molecular modelling and experimental studies of mutation and cell-adhesion sites in the fibronectin type III and whey acidic protein domains of human anosmin-1
[LiteratureReference:5653989] Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism
[LiteratureReference:5654022] The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics
modified[InstanceEdit:5654723] Rothfels, Karen, 2014-12-03
[InstanceEdit:5674993] Rothfels, Karen, 2015-02-14
[InstanceEdit:5678405] Rothfels, Karen, 2015-02-23
[InstanceEdit:5692926] Rothfels, Karen, 2015-05-13
[InstanceEdit:5693945] Rothfels, Karen, 2015-05-19
[InstanceEdit:6808669] Rothfels, Karen, 2015-11-08
[InstanceEdit:6809941] Rothfels, Karen, 2015-11-13
[InstanceEdit:8851413] Rothfels, Karen, 2016-01-06
[InstanceEdit:8865224] Rothfels, Karen, 2016-03-21
[InstanceEdit:8874452] Weiser, JD
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameKAL1 binds FGFR1c
output[Complex:5654346] FGFR1c:KAL1 [plasma membrane] [Homo sapiens]
releaseDate2016-03-23
releaseStatusUPDATED
reviewed[InstanceEdit:8851383] Nishimura, Tatsunori, 2016-01-06
[InstanceEdit:8851378] Grose, Richard P, 2016-01-06
[InstanceEdit:8865033] Gotoh, N, 2016-03-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861203] R-HSA-5654514.3
summation[Summation:5654373] KAL1 is an extracellular matrix-associated protein that modu...
(hasEvent)[Pathway:5654726] Negative regulation of FGFR1 signaling [Homo sapiens]
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