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Details on Person gain_of_function of FGFR4 enhanced kinase mutant dimers [plasma membrane]
| Class:Id | EntityFunctionalStatus:5654468 |
|---|---|
| _displayName | gain_of_function of FGFR4 enhanced kinase mutant dimers [plasma membrane] |
| _timestamp | 2018-12-18 19:00:23 |
| created | [InstanceEdit:5654469] Rothfels, Karen, 2014-12-03 |
| diseaseEntity | [CandidateSet:2038942] FGFR4 enhanced kinase mutant dimers [plasma membrane] [Homo sapiens] |
| functionalStatus | [FunctionalStatus:2362351] gain_of_function via non_conservative_missense_variant |
| modified | [InstanceEdit:9631717] Wu, G, 2018-12-12 [InstanceEdit:9632437] Rothfels, Karen, 2018-12-18 |
| normalEntity | [Complex:190223] FGFR4 homodimer bound to FGF [plasma membrane] [Homo sapiens] |
| (entityFunctionalStatus) | [Reaction:2038944] Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity [Homo sapiens] [Reaction:2046363] FGFR4 kinase mutants are inhibited by PD170734 [Homo sapiens] |
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No pathways have been reviewed or authored by gain_of_function of FGFR4 enhanced kinase mutant dimers [plasma membrane] (5654468)
