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Details on Person Activated FGFR4 phosphorylates SHC1

Class:Id	Reaction:5654428
_displayName	Activated FGFR4 phosphorylates SHC1
_doRelease	TRUE
_timestamp	2015-03-04 03:59:56
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654427] protein tyrosine kinase activity of Activated FGFR4:SHC1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654429] Rothfels, Karen, 2014-12-03
input	[Complex:5654320] Activated FGFR4:SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:532248] Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2) [LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. [LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells [LiteratureReference:532255] Fibroblast growth factor receptors have different signaling and mitogenic potentials
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR4 phosphorylates SHC1
output	[Complex:5654340] Activated FGFR4:pY-SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:5654425] Activated FGFR4 binds SHC1 [Homo sapiens] [Reaction:190326] Autocatalytic phosphorylation of FGFR4 [Homo sapiens] [Reaction:1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679992] R-HSA-5654428.2
summation	[Summation:1268280] The p46 and p53 isoforms of SHC1 have been shown to be phosp...
(hasEvent)	[Pathway:5654719] SHC-mediated cascade:FGFR4 [Homo sapiens]
(precedingEvent)	[Reaction:5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 [Homo sapiens]
(replacementInstances)	[_Deleted:5655548] Deletion of instance: 1268281
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No pathways have been reviewed or authored by Activated FGFR4 phosphorylates SHC1 (5654428)