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Details on Person Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Class:Id	Reaction:5654426
_displayName	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
_doRelease	TRUE
_timestamp	2015-03-04 04:17:26
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654424] guanyl-nucleotide exchange factor activity of Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654429] Rothfels, Karen, 2014-12-03
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
output	[SimpleEntity:29420] GDP [cytosol] [Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 [Homo sapiens] [Reaction:5654428] Activated FGFR4 phosphorylates SHC1 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680287] R-HSA-5654426.2
summation	[Summation:1268274] SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates R...
(hasEvent)	[Pathway:5654719] SHC-mediated cascade:FGFR4 [Homo sapiens]
(replacementInstances)	[_Deleted:5655544] Deletion of instance: 1268277
(updatedInstance)	[_UpdateTracker:9782516] Update Tracker - [Reaction:5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - v59:[removeRegulator]
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No pathways have been reviewed or authored by Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (5654426)