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Details on Person Activated FGFR4:p-SHC1 binds GRB2:SOS1

Class:Id	Reaction:5654423
_displayName	Activated FGFR4:p-SHC1 binds GRB2:SOS1
_doRelease	TRUE
_timestamp	2015-03-04 04:16:44
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5654429] Rothfels, Karen, 2014-12-03
input	[Complex:5654340] Activated FGFR4:pY-SHC1 [plasma membrane] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells [LiteratureReference:191036] Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells [LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR4:p-SHC1 binds GRB2:SOS1
output	[Complex:5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654428] Activated FGFR4 phosphorylates SHC1 [Homo sapiens] [Reaction:5654425] Activated FGFR4 binds SHC1 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680273] R-HSA-5654423.2
summation	[Summation:532256] Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) l...
(hasEvent)	[Pathway:5654719] SHC-mediated cascade:FGFR4 [Homo sapiens]
(precedingEvent)	[Reaction:5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(replacementInstances)	[_Deleted:5655547] Deletion of instance: 1268258
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No pathways have been reviewed or authored by Activated FGFR4:p-SHC1 binds GRB2:SOS1 (5654423)