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Details on Person Activated FGFR4 phosphorylates FRS2

Class:Id	Reaction:5654418
_displayName	Activated FGFR4 phosphorylates FRS2
_doRelease	TRUE
_timestamp	2015-03-04 03:56:51
authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:5654419] protein tyrosine kinase activity of Activated FGFR4:FRS2 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5654421] Rothfels, Karen, 2014-12-03
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:5654182] Activated FGFR4:FRS2 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:532232] Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 [LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
modified	[InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR4 phosphorylates FRS2
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:5654193] Activated FGFR4:p-FRS2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654422] Activated FGFR4 binds FRS2 [Homo sapiens] [Reaction:190326] Autocatalytic phosphorylation of FGFR4 [Homo sapiens] [Reaction:1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 [Homo sapiens]
regulatedBy	[NegativeRegulation:5654420] Negative regulation by 'Activated FGFR4:p-8T-FRS2 [plasma membrane]'
releaseDate	2010-03-16
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679921] R-HSA-5654418.3
summation	[Summation:191507] FRS2 (also known as FRS alpha is activated through tyrosine...
(hasEvent)	[Pathway:5654712] FRS-mediated FGFR4 signaling [Homo sapiens]
(normalReaction)	[Reaction:5655284] Activated FGFR4 mutants phosphorylate FRS2 [Homo sapiens]
(precedingEvent)	[Reaction:5654658] Activated FGFR4:p-FRS bind to PPTN11 [Homo sapiens] [Reaction:5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens] [Reaction:5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 [Homo sapiens]
(replacementInstances)	[_Deleted:5655568] Deletion of instance: 190353
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