Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Activated FGFR3:pFRS binds GRB2:SOS1

Class:Id	Reaction:5654416
_displayName	Activated FGFR3:pFRS binds GRB2:SOS1
_doRelease	TRUE
_timestamp	2017-03-15 14:13:51
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654414] Rothfels, Karen, 2014-12-03
input	[DefinedSet:5654305] Activated FGFR3:p-FRS [plasma membrane] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:532232] Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 [LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells [LiteratureReference:191015] Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
modified	[InstanceEdit:5691277] Rothfels, Karen, 2015-05-05 [InstanceEdit:8981908] Rothfels, Karen, 2017-03-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3:pFRS binds GRB2:SOS1
output	[Complex:5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5654408] Activated FGFR3 phosphorylates FRS2 [Homo sapiens] [Reaction:5654409] Activated FGFR3 binds FRS2 [Homo sapiens] [Reaction:5654628] Activated FGFR3 phosphorylates FRS3 [Homo sapiens] [Reaction:5654623] Activated FGFR3 binds FRS3 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679689] R-HSA-5654416.3
summation	[Summation:1268254] Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by m...
(hasEvent)	[Pathway:5654706] FRS-mediated FGFR3 signaling [Homo sapiens]
(normalReaction)	[Reaction:5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 [Homo sapiens]
(precedingEvent)	[Reaction:5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(replacementInstances)	[_Deleted:5655561] Deletion of instance: 1268255
[Change default viewing format]

No pathways have been reviewed or authored by Activated FGFR3:pFRS binds GRB2:SOS1 (5654416)