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Details on Person Activated FGFR3 binds FRS2

Class:Id	Reaction:5654409
_displayName	Activated FGFR3 binds FRS2
_doRelease	TRUE
_timestamp	2015-03-04 04:06:38
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654410] Rothfels, Karen, 2014-12-03
input	[DefinedSet:5654146] Activated FGFR3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:170963] FRS2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:182133] FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors [LiteratureReference:532259] Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR3 binds FRS2
output	[Complex:5654180] Activated FGFR3:FRS2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:190385] Autocatalytic phosphorylation of FGFR3b [Homo sapiens] [Reaction:190263] FGFR3b binds to FGF [Homo sapiens] [Reaction:190388] Autocatalytic phosphorylation of FGFR3c [Homo sapiens] [Reaction:190261] FGFR3c binds to FGF [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680100] R-HSA-5654409.2
summation	[Summation:1268219] FRS2 (also known as FRS2alpha) is broadly expressed in adult...
(hasEvent)	[Pathway:5654706] FRS-mediated FGFR3 signaling [Homo sapiens]
(normalReaction)	[Reaction:5655262] Activated FGFR3 point, translocation and fusion mutants bind FRS2 [Homo sapiens]
(precedingEvent)	[Reaction:5654408] Activated FGFR3 phosphorylates FRS2 [Homo sapiens]
(replacementInstances)	[_Deleted:5655573] Deletion of instance: 1268220
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No pathways have been reviewed or authored by Activated FGFR3 binds FRS2 (5654409)