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Details on Person A complex of LAMTOR1 to 5, known as Ragulator, interacts wit...

Class:IdSummation:5653918
_displayNameA complex of LAMTOR1 to 5, known as Ragulator, interacts wit...
_timestamp2026-01-30 16:38:42
created[InstanceEdit:5653922] Jupe, Steve, 2014-12-03
literatureReference[LiteratureReference:5653913] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
[LiteratureReference:5653937] The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes
[LiteratureReference:5653914] Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
[LiteratureReference:5653933] A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14
modified[InstanceEdit:5653941] Jupe, Steve, 2014-12-03
[InstanceEdit:5655428] Jupe, Steve, 2014-12-05
[InstanceEdit:5693184] Jupe, Steve, 2015-05-14
[InstanceEdit:9980586] Orlic-Milacic, Marija, 2026-01-30
textA complex of LAMTOR1 to 5, known as Ragulator, interacts with Rag GTPases recruiting them to lysosomes, an essential step in mTORC1 activation (Sancak et al. 2010). LAMTOR1 is probably myristoylated and/or palmitoylated to enhance its association with the lysosomal surface, acting as a platform for the other members of the complex. Lamtor1 (Nada et al. 2009) and Lamtor2 (Teis et al. 2006) knockout mice exhibit severe growth retardation, severe defects in intracellular organelle organization and embryonic lethality. Partial reduction of LAMTOR2 in humans leads to reduced height (Bohn et al. 2007).
(summation)[Reaction:5653936] Formation of Ragulator complex [Homo sapiens]
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