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Details on Person B4GALT1 binds LALBA

Class:Id	Reaction:5653886
_displayName	B4GALT1 binds LALBA
_doRelease	TRUE
_timestamp	2025-03-26 19:17:21
catalystActivity	[CatalystActivity:9941993] enzyme-substrate adaptor activity of LALBA [Golgi lumen]
catalystActivityReference	[CatalystActivityReference:9941991] enzyme-substrate adaptor activity of LALBA [Golgi lumen] Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:5653879] D'Eustachio, Peter, 2014-12-02
input	[EntityWithAccessionedSequence:528072] B4GALT1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:5653896] LALBA [Golgi lumen] [Homo sapiens]
internalReviewed	[InstanceEdit:9942000] D'Eustachio, Peter, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:5653880] Purification of lactose synthetase a protein from human milk and demonstration of its interaction with alpha-lactalbumin [LiteratureReference:5653887] Lactose biosynthesis [LiteratureReference:5653877] Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
modified	[InstanceEdit:5655210] D'Eustachio, Peter, 2014-12-05 [InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:5668964] D'Eustachio, Peter, 2015-01-29 [InstanceEdit:5674546] D'Eustachio, Peter, 2015-02-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941995] D'Eustachio, Peter, 2025-03-12 [InstanceEdit:9941999] D'Eustachio, Peter, 2025-03-12 [InstanceEdit:9943298] D'Eustachio, Peter, 2025-03-26
name	B4GALT1 binds LALBA
output	[Complex:5653885] B4GALT1:LALBA [Golgi membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:5653872] Positive regulation by 'UDP-Gal [Golgi lumen]' [PositiveRegulation:5653876] Positive regulation by 'Mn2+ [Golgi lumen]'
regulationReference	[RegulationReference:9641506] Positive regulation by 'Mn2+ [Golgi lumen]' Lactose biosynthesis [RegulationReference:9642727] Positive regulation by 'UDP-Gal [Golgi lumen]' Lactose biosynthesis
releaseDate	2013-12-04
reviewed	[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:9943299] Hill, David P, 2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679869] R-HSA-5653886.6
structureModified	[InstanceEdit:9941995] D'Eustachio, Peter, 2025-03-12
summation	[Summation:5655207] B4GALT1 (beta-1,4-galactosyltransferase 1) in the Golgi memb...
(hasEvent)	[Pathway:5653890] Lactose synthesis [Homo sapiens]
(precedingEvent)	[Reaction:5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953754] Update Tracker - [Reaction:5653886] B4GALT1 binds LALBA - v93:[removeCatalystActivity]
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