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Details on Person B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac

Class:Id	Reaction:5653878
_displayName	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac
_doRelease	TRUE
_timestamp	2025-03-26 19:17:21
catalystActivity	[CatalystActivity:5653894] lactose synthase activity of B4GALT1:LALBA [Golgi membrane]
catalystActivityReference	[CatalystActivityReference:9643898] lactose synthase activity of B4GALT1:LALBA [Golgi membrane] Lactose biosynthesis
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:5653879] D'Eustachio, Peter, 2014-12-02
crossReference	[DatabaseIdentifier:9941994] RHEA:12405
input	[SimpleEntity:964746] Glc [Golgi lumen] [SimpleEntity:735682] UDP-Gal [Golgi lumen]
internalReviewed	[InstanceEdit:9942000] D'Eustachio, Peter, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:5653880] Purification of lactose synthetase a protein from human milk and demonstration of its interaction with alpha-lactalbumin [LiteratureReference:5653887] Lactose biosynthesis [LiteratureReference:5653877] Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
modified	[InstanceEdit:5655210] D'Eustachio, Peter, 2014-12-05 [InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:5668964] D'Eustachio, Peter, 2015-01-29 [InstanceEdit:5674546] D'Eustachio, Peter, 2015-02-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941995] D'Eustachio, Peter, 2025-03-12 [InstanceEdit:9941999] D'Eustachio, Peter, 2025-03-12 [InstanceEdit:9943298] D'Eustachio, Peter, 2025-03-26
name	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac UDP-alpha-D-galactose + D-glucose => lactose + UDP + H(+) Glc + UDP-Gal => Lac + UDP
output	[SimpleEntity:5653871] Lac [Golgi lumen] [SimpleEntity:205687] UDP [Golgi lumen] [SimpleEntity:425969] H+ [Golgi lumen]
precedingEvent	[Reaction:5653886] B4GALT1 binds LALBA [Homo sapiens] [Reaction:5653873] SLC2A1 tetramer transports Glc from cytosol to Golgi lumen [Homo sapiens] [Reaction:735702] SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-03-19
reviewed	[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:9943299] Hill, David P, 2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680307] R-HSA-5653878.5
structureModified	[InstanceEdit:9941995] D'Eustachio, Peter, 2025-03-12
summation	[Summation:5655208] In the Golgi membrane, the B4GALT1 subunit of the B4GALT1:LA...
(hasEvent)	[Pathway:5653890] Lactose synthesis [Homo sapiens]
(precedingEvent)	[Reaction:9839042] Lac [cytosol]->LNTri II [cytosol] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953653] Update Tracker - [Reaction:5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - v93:[removeOutput]
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