Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:O00291 HIP1

Class:Id	ReferenceGeneProduct:56526
_chainChangeLog	chain:1-1037 added on Fri February 6 2015
_displayName	UniProt:O00291 HIP1
_timestamp	2024-11-03 19:56:38
chain	chain:1-1037
checksum	F8C0369DBF0A836F
comment	FUNCTION Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454).SUBUNIT Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N-terminus). Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts with GRIA1, GRIN2A and GRIN2B.INTERACTION Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.ALTERNATIVE PRODUCTS Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.DOMAIN The pseudo DED region (pDED) mediates the interaction with IFT57.DOMAIN Binds F-actin via the talin-like I/LWEQ domain.DISEASE A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).MISCELLANEOUS The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.SIMILARITY Belongs to the SLA2 family.
description	recommendedName: Huntingtin-interacting protein 1 shortName: HIP-1 alternativeName: Huntingtin-interacting protein I shortName: HIP-I
geneName	HIP1
identifier	O00291
isSequenceChanged	FALSE
keyword	3D-structure Actin-binding Activator Alternative splicing Apoptosis Chromosomal rearrangement Coiled coil Cytoplasm Cytoplasmic vesicle Differentiation Endocytosis Membrane Neurodegeneration Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	HIP1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8996622] ENSEMBL:ENSG00000127946 HIP1 [Homo sapiens]
secondaryIdentifier	HIP1_HUMAN B4E3I7 E7ES17 O00328 Q2TB58 Q8TDL4 V5LU97
sequenceLength	1037
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:148420] UniProt:O00291-2 HIP1 [Homo sapiens] [ReferenceIsoform:401102] UniProt:O00291-1 HIP1 [Homo sapiens] [ReferenceIsoform:8965634] UniProt:O00291-3 HIP1 [Homo sapiens] [ReferenceIsoform:8965635] UniProt:O00291-4 HIP1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:8868153] HIP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711952] HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711956] HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711965] HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711970] HIP1(1-1019)-ALK(1058-1620) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711972] HIP1(1-963)-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9711975] HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] [Homo sapiens]
(referenceSequence)	[FragmentReplacedModification:9711923] Replacement of residues 719 to 719 by DL
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:O00291 HIP1 (56526)