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Details on Person SORD oxidizes D-sorbitol to Fru

Class:Id	Reaction:5652195
_displayName	SORD oxidizes D-sorbitol to Fru
_doRelease	TRUE
_timestamp	2023-05-30 20:57:15
authored	[InstanceEdit:6792817] Cameselle, Jos� Carlos, Ribeiro, Jo�o Meireles, 2015-08-27 [InstanceEdit:5652219] D'Eustachio, Peter, 2014-11-28
catalystActivity	[CatalystActivity:5652209] L-iditol 2-dehydrogenase (NAD+) activity of SORD tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643825] L-iditol 2-dehydrogenase activity of SORD tetramer [cytosol] Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5652219] D'Eustachio, Peter, 2014-11-28
edited	[InstanceEdit:5652219] D'Eustachio, Peter, 2014-11-28
input	[SimpleEntity:5652213] D-sorbitol [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5652192] [The mechanism of the formation of seminal fructose and fetal fructose] [LiteratureReference:5652208] Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme [LiteratureReference:5652217] Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase [LiteratureReference:5652201] X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase
modified	[InstanceEdit:5652228] D'Eustachio, Peter, 2014-11-28 [InstanceEdit:5661210] D'Eustachio, Peter, 2015-01-09 [InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:5668967] D'Eustachio, Peter, 2015-01-29 [InstanceEdit:5674542] D'Eustachio, Peter, 2015-02-12 [InstanceEdit:6792826] D'Eustachio, Peter, 2015-08-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9670648] D'Eustachio, Peter, 2019-12-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9832974] D'Eustachio, Peter, 2023-04-11 [InstanceEdit:9835574] D'Eustachio, Peter, 2023-05-16 [InstanceEdit:9836604] D'Eustachio, Peter, 2023-05-30
name	SORD oxidizes D-sorbitol to Fru D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH sorbitol + NAD+ => fructose + NADH + H+
output	[SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:9832975] keto-D-Fru [cytosol]
precedingEvent	[Reaction:5652172] AKR1B1 reduces Glc to D-sorbitol [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-12-04
reviewed	[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:9835575] Hill, David P, 2023-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680257] R-HSA-5652195.7
structureModified	[InstanceEdit:9832974] D'Eustachio, Peter, 2023-04-11
summation	[Summation:5652198] Cytosolic SORD (sorbitol dehydrogenase) catalyzes the reacti...
(hasEvent)	[Pathway:5652227] Fructose biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:70333] KHK dimer phosphorylates Fru to Fru 1-P [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9835742] Update Tracker - [Reaction:5652195] SORD oxidizes D-sorbitol to Fru - v85:[add_removeOutput]
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