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Details on Person RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA

Class:IdReaction:5652009
_displayNameRAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
_doReleaseTRUE
_timestamp2015-03-04 04:11:28
authored[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity[CatalystActivity:5652007] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643528] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5652010] Orlic-Milacic, Marija, 2014-11-26
edited[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
input[Complex:5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5651998] RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
[LiteratureReference:5653648] Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis
[LiteratureReference:5653644] Trading places: how do DNA polymerases switch during translesion DNA synthesis?
[LiteratureReference:5655179] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
[LiteratureReference:5655463] CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
modified[InstanceEdit:5653653] Orlic-Milacic, Marija, 2014-12-01
[InstanceEdit:5655201] Orlic-Milacic, Marija, 2014-12-04
[InstanceEdit:5655465] Orlic-Milacic, Marija, 2014-12-05
[InstanceEdit:5663021] Orlic-Milacic, Marija, 2015-01-14
[InstanceEdit:5663081] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:5663087] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:5663090] Orlic-Milacic, Marija, 2015-01-15
[InstanceEdit:5674553] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
output[Complex:5652003] MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] [Homo sapiens]
[CandidateSet:5651800] POLD,POLE [nucleoplasm] [Homo sapiens]
[DefinedSet:5655459] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-03-19
reviewed[InstanceEdit:5663080] Borowiec, James, 2015-01-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680187] R-HSA-5652009.3
summation[Summation:5652008] The complex of RAD18, an E3 ubiquitin ligase, and UBE2B (RAD...
(hasEvent)[Pathway:110314] Recognition of DNA damage by PCNA-containing replication complex [Homo sapiens]
(precedingEvent)[Reaction:110307] REV1 binds AP-dsDNA [Homo sapiens]
[Reaction:110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template [Homo sapiens]
[Reaction:5655481] USP1:WDR48 binds monoUb:K164-PCNA [Homo sapiens]
[Reaction:5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template [Homo sapiens]
[Reaction:5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA [Homo sapiens]
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No pathways have been reviewed or authored by RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (5652009)
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