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Details on Person RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA

Class:Id	Reaction:5652005
_displayName	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA
_doRelease	TRUE
_timestamp	2015-03-04 03:48:08
authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5651999] Orlic-Milacic, Marija, 2014-11-26
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
input	[Complex:5651995] PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] [Homo sapiens] [DefinedSet:5655459] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5651998] RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO [LiteratureReference:5651996] Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a [LiteratureReference:5651988] Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification [LiteratureReference:5655463] CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
modified	[InstanceEdit:5655465] Orlic-Milacic, Marija, 2014-12-05 [InstanceEdit:5656186] Orlic-Milacic, Marija, 2014-12-11 [InstanceEdit:5663081] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663087] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663090] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5674553] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA
output	[Complex:5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5651992] PCNA-containing replication complex binds damaged dsDNA [Homo sapiens] [BlackBoxEvent:5652137] Damaged dsDNA becomes damaged DNA template [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679770] R-HSA-5652005.2
summation	[Summation:5652004] The complex of RAD18, an E3 ubiquitin ligase, and UBE2B (RAD...
(hasEvent)	[Pathway:110314] Recognition of DNA damage by PCNA-containing replication complex [Homo sapiens]
(precedingEvent)	[Reaction:5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA [Homo sapiens]
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No pathways have been reviewed or authored by RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (5652005)