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Details on Person DNA polymerase beta (POLB) catalyzes DNA strand displacement...
| Class:Id | Summation:5651662 |
|---|---|
| _displayName | DNA polymerase beta (POLB) catalyzes DNA strand displacement... |
| _timestamp | 2014-12-22 19:34:20 |
| created | [InstanceEdit:5651661] Orlic-Milacic, Marija, 2014-11-24 |
| modified | [InstanceEdit:5651728] Orlic-Milacic, Marija, 2014-11-24 [InstanceEdit:5651937] Orlic-Milacic, Marija, 2014-11-26 [InstanceEdit:5659692] Orlic-Milacic, Marija, 2014-12-22 [InstanceEdit:5659707] Orlic-Milacic, Marija, 2014-12-22 |
| text | DNA polymerase beta (POLB) catalyzes DNA strand displacement synthesis. In this process, 2-10 nucleotides (dNMPs) are incorporated at the 3' end of the single strand break (SSB). Simultaneously, the other broken DNA strand, which contains a 5' oxidatively-damaged AP dideoxyribose phosphate residue (5'ddRP), is displaced as a flap structure. POLB-mediated DNA strand displacement synthesis is facilitated by PARP1 and/or PARP2 dimers, which bind the single strand DNA (ssDNA) ends and FEN1 (flap endonuclease) (Klungland and Lindahl 1997, Prasad et al. 2001, Lavrik et al. 2001, Liu et al. 2005). |
| (summation) | [Reaction:5649883] POLB-mediated DNA strand displacement synthesis [Homo sapiens] |
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No pathways have been reviewed or authored by DNA polymerase beta (POLB) catalyzes DNA strand displacement... (5651662)
