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Details on Person UniProt:P35367 HRH1
| Class:Id | ReferenceGeneProduct:56502 |
|---|---|
| _chainChangeLog | chain:1-487 added on Fri February 6 2015 |
| _displayName | UniProt:P35367 HRH1 |
| _timestamp | 2024-11-03 19:51:37 |
| chain | chain:1-487 |
| checksum | E5DB418A4C17A985 |
| comment | FUNCTION G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity).SUBCELLULAR LOCATION Histamine activates the receptor by forming hydrogen bonds with transmembrane domains 3 and 6, squashing the ligand-binding pocket on the extracellular side and opening the cavity for G-protein engagement on the intracellular side.PTM Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: fullName evidence="11"Histamine H1 receptor shortName evidence="11"H1-R shortName evidence="10"H1R shortName: HH1R |
| geneName | HRH1 |
| identifier | P35367 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HRH1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988997] ENSEMBL:ENSG00000196639 HRH1 [Homo sapiens] |
| secondaryIdentifier | HRH1_HUMAN A8K047 Q6P9E5 |
| sequenceLength | 487 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:390908] HRH1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35367 HRH1 (56502)
