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Details on Person POLB-mediated DNA strand displacement synthesis

Class:Id	Reaction:5649883
_displayName	POLB-mediated DNA strand displacement synthesis
_doRelease	TRUE
_timestamp	2017-04-28 16:03:26
authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
catalystActivity	[CatalystActivity:5649867] DNA-directed DNA polymerase activity of PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649875] Orlic-Milacic, Marija, 2014-11-21
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[Complex:5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm] [SimpleEntity:30555] dNTP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5649874] DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis [LiteratureReference:5649870] Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair [LiteratureReference:111248] Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). [LiteratureReference:5651720] DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair
modified	[InstanceEdit:5651663] Orlic-Milacic, Marija, 2014-11-24 [InstanceEdit:5651728] Orlic-Milacic, Marija, 2014-11-24 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:8986543] Orlic-Milacic, Marija, 2017-04-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLB-mediated DNA strand displacement synthesis
output	[Complex:5649888] PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [Homo sapiens] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm]
precedingEvent	[Reaction:5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site [Homo sapiens] [Reaction:111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680124] R-HSA-5649883.3
summation	[Summation:5651662] DNA polymerase beta (POLB) catalyzes DNA strand displacement...
(hasEvent)	[Pathway:110362] POLB-Dependent Long Patch Base Excision Repair [Homo sapiens]
(precedingEvent)	[Reaction:5651723] PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate [Homo sapiens]
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No pathways have been reviewed or authored by POLB-mediated DNA strand displacement synthesis (5649883)