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Details on Person PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site

Class:IdReaction:5649873
_displayNamePARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
_doReleaseTRUE
_timestamp2017-04-28 16:02:08
authored[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5649875] Orlic-Milacic, Marija, 2014-11-21
edited[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input[Complex:5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens]
[Complex:5649884] PARP1,PARP2 dimers [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:54745] FEN1 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5649874] DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis
[LiteratureReference:5649870] Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair
[LiteratureReference:5649877] AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate
[LiteratureReference:5651851] PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
[LiteratureReference:5651857] Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers
[LiteratureReference:5651866] Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
[LiteratureReference:5651836] Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
modified[InstanceEdit:5651663] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651841] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651870] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5659691] Orlic-Milacic, Marija, 2014-12-22
[InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11
[InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:8986542] Orlic-Milacic, Marija, 2017-04-28
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
output[Complex:5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:50119] APEX1 [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:8986540] Positive regulation by 'PARG [nucleoplasm]'
regulationReference[RegulationReference:9642005] Positive regulation by 'PARG [nucleoplasm]' Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
releaseDate2015-03-19
reviewed[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5680089] R-HSA-5649873.5
summation[Summation:5651660] Homodimers and/or heterodimers of PARP1 and PARP2 bind singl...
(hasEvent)[Pathway:110362] POLB-Dependent Long Patch Base Excision Repair [Homo sapiens]
(precedingEvent)[Reaction:5649883] POLB-mediated DNA strand displacement synthesis [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781113] Update Tracker - [Reaction:5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - v61:[addRegulator]
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