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Details on Person WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)

Class:IdReaction:5649802
_displayNameWHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)
_doReleaseTRUE
_timestamp2015-03-04 03:43:58
authored[InstanceEdit:5638142] Jupe, Steve, 2014-11-13
catalystActivity[CatalystActivity:5159247] histone H3 methyltransferase activity of WHSC1, WHSC1L1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5649755] Jupe, Steve, 2014-11-21
edited[InstanceEdit:5674564] Jupe, Steve, 2015-02-13
input[CandidateSet:5649790] Me2K28-histone H3 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:5638330] Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity
[LiteratureReference:5637676] Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity
modified[InstanceEdit:5649808] Jupe, Steve, 2014-11-21
[InstanceEdit:5651717] Jupe, Steve, 2014-11-24
[InstanceEdit:5674415] Jupe, Steve, 2015-02-12
[InstanceEdit:5674563] Jupe, Steve, 2015-02-13
[InstanceEdit:5674565] Jupe, Steve, 2015-02-13
[InstanceEdit:5676065] Jupe, Steve, 2015-02-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameWHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)
WHSC1L1 (KMT3F) methylates Me2K28-histone H3 (H3K27)
WHSC1L1 methylates Me2K28-histone H3
output[CandidateSet:5649781] Me3K28-histone H3 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate2015-03-15
reviewed[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5679694] R-HSA-5649802.2
summation[Summation:5649756] WHSC1 (MMSET, KMT3G) is able to mono-, di- and trimethylate ...
systematicNameWHSC1L1 transfers CH3 from AdoMet to Me2K28-histone H3
(hasEvent)[Pathway:3214841] PKMTs methylate histone lysines [Homo sapiens]
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