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Details on Person UniProt:P14210 HGF
| Class:Id | ReferenceGeneProduct:56498 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Sat February 7 2015;chain:32-494 added on Sat February 7 2015;chain:495-728 added on Sat February 7 2015 |
| _displayName | UniProt:P14210 HGF |
| _timestamp | 2025-08-15 22:00:59 |
| chain | signal peptide:1-31 chain:32-494 chain:495-728 |
| checksum | 2D997938295ADD2F |
| comment | FUNCTION Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:15167892, PubMed:20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675).SUBUNIT Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.INTERACTION The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form (PubMed:20977675). The single-chain precursor undergoes proteolytic processing by HGFAC resulting in an active two-chain form (PubMed:8226803).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Acts as a competitive antagonist in MET-signaling.SIMILARITY Belongs to the peptidase S1 family. Plasminogen subfamily.CAUTION Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.ONLINE INFORMATION Hepatocyte growth factor entry |
| description | recommendedName: Hepatocyte growth factor alternativeName: Hepatopoietin-A alternativeName: Scatter factor shortName: SF component recommendedName: Hepatocyte growth factor alpha chain /component component recommendedName: Hepatocyte growth factor beta chain /component |
| geneName | HGF HPTA |
| identifier | P14210 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Deafness Direct protein sequencing Disulfide bond Glycoprotein Growth factor Kringle Non-syndromic deafness Proteomics identification Pyrrolidone carboxylic acid Reference proteome Repeat Serine protease homolog Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | HGF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8948374] ENSEMBL:ENSG00000019991 HGF [Homo sapiens] |
| secondaryIdentifier | HGF_HUMAN A1L3U6 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6 |
| sequenceLength | 728 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:148383] UniProt:P14210-2 HGF [Homo sapiens] [ReferenceIsoform:148384] UniProt:P14210-3 HGF [Homo sapiens] [ReferenceIsoform:148385] UniProt:P14210-4 HGF [Homo sapiens] [ReferenceIsoform:148386] UniProt:P14210-5 HGF [Homo sapiens] [ReferenceIsoform:148387] UniProt:P14210-6 HGF [Homo sapiens] [ReferenceIsoform:402948] UniProt:P14210-1 HGF [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:56497] HGF(32-494) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:139866] HGF(32-494) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:141764] HGF(495-728) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:141767] HGF(495-728) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6800218] pro-HGF [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P14210 HGF (56498)
