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Details on Person DOT1L is responsible for the mono-, di-, and trimethylation ...

Class:IdSummation:5649797
_displayNameDOT1L is responsible for the mono-, di-, and trimethylation ...
_timestamp2014-11-21 15:50:53
created[InstanceEdit:5649755] Jupe, Steve, 2014-11-21
literatureReference[LiteratureReference:5649787] Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase
[LiteratureReference:5649770] Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states
[LiteratureReference:5634731] Dot1p modulates silencing in yeast by methylation of the nucleosome core
[LiteratureReference:5649794] Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase
[LiteratureReference:5649769] The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure
modified[InstanceEdit:5649808] Jupe, Steve, 2014-11-21
textDOT1L is responsible for the mono-, di-, and trimethylation of histone H3 in a nonprocessive manner (Min et al. 2003, Frederiks et al. 2008). It appear to be solely responsible for H3K79 methylation, since knockout of Dot1 in yeast, flies and mice results in complete loss of H3K79 methylation (van Leeuwen et al. 2002, Shanower et al. 2005, Jones et al. 2008).
(summation)[Reaction:5649799] DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) [Homo sapiens]
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