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Details on Person DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)

Class:Id	Reaction:5649764
_displayName	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)
_doRelease	TRUE
_timestamp	2015-03-04 03:53:34
authored	[InstanceEdit:5638142] Jupe, Steve, 2014-11-13
catalystActivity	[CatalystActivity:5649792] histone H3 methyltransferase activity of DOT1L [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649755] Jupe, Steve, 2014-11-21
edited	[InstanceEdit:5674564] Jupe, Steve, 2015-02-13
input	[CandidateSet:5649758] MeK80-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5634728] Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
modified	[InstanceEdit:5649808] Jupe, Steve, 2014-11-21 [InstanceEdit:5651717] Jupe, Steve, 2014-11-24 [InstanceEdit:5674398] Jupe, Steve, 2015-02-12 [InstanceEdit:5674563] Jupe, Steve, 2015-02-13 [InstanceEdit:5674565] Jupe, Steve, 2015-02-13 [InstanceEdit:5676065] Jupe, Steve, 2015-02-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) DOT1L methylates methyl-lysine-80 of histone H3
output	[CandidateSet:5649783] Me2K80-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2015-03-15
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679874] R-HSA-5649764.2
summation	[Summation:5649804] DOT1L is capable of catalyzing the mono-, di-, and trimethyl...
systematicName	DOT1L transfers CH3 from AdoMet to MeK80-histone H3
(hasEvent)	[Pathway:3214841] PKMTs methylate histone lysines [Homo sapiens]
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No pathways have been reviewed or authored by DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (5649764)