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Details on Person NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]

Class:Id	Complex:5649729
_displayName	NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]
_timestamp	2015-03-04 05:26:23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649732] Orlic-Milacic, Marija, 2014-11-21
hasComponent	[Complex:5649730] NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] [Homo sapiens] [CandidateSet:5649697] NEIL1,NEIL2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:53845] POLB [nucleoplasm] [Homo sapiens] [GenomeEncodedEntity:5649821] SSB(3'Pi)-gap-dsDNA [nucleoplasm] [Homo sapiens] [Complex:110338] LIG3:XRCC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:67455] XRCC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:53789] LIG3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5649651] PNKP [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5649703] AP endonuclease-independent DNA base excision repair in human cells [LiteratureReference:5649714] NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells [LiteratureReference:5649812] XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair
modified	[InstanceEdit:5649833] Orlic-Milacic, Marija, 2014-11-21
name	NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5681129] R-HSA-5649729.1
(input)	[Reaction:5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) [Homo sapiens]
(output)	[Reaction:5649726] LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [Homo sapiens]
(physicalEntity)	[CatalystActivity:5649709] polynucleotide 3'-phosphatase activity of NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm]
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No pathways have been reviewed or authored by NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (5649729)