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Details on Person POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)

Class:Id	Reaction:5649725
_displayName	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)
_doRelease	TRUE
_timestamp	2015-03-04 04:00:34
authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
catalystActivity	[CatalystActivity:5649731] DNA-(apurinic or apyrimidinic site) endonuclease activity of NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649732] Orlic-Milacic, Marija, 2014-11-21
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[Complex:5649715] NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5649703] AP endonuclease-independent DNA base excision repair in human cells [LiteratureReference:5649714] NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells
modified	[InstanceEdit:5649809] Orlic-Milacic, Marija, 2014-11-21 [InstanceEdit:5649810] Orlic-Milacic, Marija, 2014-11-21 [InstanceEdit:5649837] Orlic-Milacic, Marija, 2014-11-21 [InstanceEdit:5649850] Orlic-Milacic, Marija, 2014-11-21 [InstanceEdit:5659685] Orlic-Milacic, Marija, 2014-12-22 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)
output	[Complex:5649730] NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] [Homo sapiens] [SimpleEntity:30977] SUGP [nucleoplasm]
precedingEvent	[Reaction:5649708] NEIL1,NEIL2 recruits POLB to incised AP site [Homo sapiens] [Reaction:5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680000] R-HSA-5649725.2
summation	[Summation:5649814] POLB (DNA polymerase beta) acts as a 5'-exonuclease to remov...
(hasEvent)	[Pathway:5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway [Homo sapiens]
(precedingEvent)	[Reaction:5649726] LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [Homo sapiens]
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No pathways have been reviewed or authored by POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (5649725)