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Details on Person NEIL1,NEIL2 incises DNA strand 5' to the AP site

Class:IdReaction:5649711
_displayNameNEIL1,NEIL2 incises DNA strand 5' to the AP site
_doReleaseTRUE
_timestamp2015-03-04 03:59:47
authored[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
catalystActivity[CatalystActivity:5649717] DNA-(apurinic or apyrimidinic site) endonuclease activity of NEIL1,NEIL2:AP-dsDNA [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5649712] Orlic-Milacic, Marija, 2014-11-20
edited[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input[Complex:5649693] NEIL1,NEIL2:AP-dsDNA [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5649703] AP endonuclease-independent DNA base excision repair in human cells
[LiteratureReference:5649714] NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells
modified[InstanceEdit:5649850] Orlic-Milacic, Marija, 2014-11-21
[InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11
[InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNEIL1,NEIL2 incises DNA strand 5' to the AP site
output[Complex:5649706] NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-03-19
reviewed[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5679990] R-HSA-5649711.2
summation[Summation:5649713] NEIL1 or NEIL2 bound to AP-dsDNA (DNA with apurinic/apyrimid...
(hasEvent)[Pathway:5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway [Homo sapiens]
(precedingEvent)[Reaction:5649708] NEIL1,NEIL2 recruits POLB to incised AP site [Homo sapiens]
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