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Details on Person UniProt:Q93099 HGD
| Class:Id | ReferenceGeneProduct:56492 |
|---|---|
| _chainChangeLog | chain:1-445 added on Fri February 6 2015 |
| _displayName | UniProt:Q93099 HGD |
| _timestamp | 2024-11-03 19:46:07 |
| chain | chain:1-445 |
| checksum | F99B51C134FFF965 |
| comment | FUNCTION Catalyzes the conversion of homogentisate to maleylacetoacetate.CATALYTIC ACTIVITY homogentisate + O2 = 4-maleylacetoacetate + H(+)COFACTOR Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.SUBUNIT Homohexamer arranged as a dimer of trimers.INTERACTION Highest expression in the prostate, small intestine, colon, kidney and liver.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the homogentisate dioxygenase family. |
| description | recommendedName: Homogentisate 1,2-dioxygenase ecNumber evidence="14"1.13.11.5 alternativeName: Homogentisate oxygenase alternativeName: Homogentisic acid oxidase alternativeName: Homogentisicase |
| geneName | HGD HGO |
| identifier | Q93099 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Dioxygenase Disease variant Iron Metal-binding Oxidoreductase Phenylalanine catabolism Proteomics identification Reference proteome Tyrosine catabolism |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HGD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002985] ENSEMBL:ENSG00000113924 HGD [Homo sapiens] |
| secondaryIdentifier | HGD_HUMAN A8K417 B2R8Z0 |
| sequenceLength | 445 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:71075] HGD [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q93099 HGD (56492)
