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Details on Person UniProt:P81172 HAMP

Class:Id	ReferenceGeneProduct:56458
_chainChangeLog	signal peptide:1-24 added on Fri February 6 2015;propeptide:25-54 added on Fri February 6 2015;peptide:60-84 added on Fri February 6 2015;peptide:65-84 added on Fri February 6 2015
_displayName	UniProt:P81172 HAMP
_timestamp	2024-11-03 20:01:14
chain	signal peptide:1-24 propeptide:25-54 peptide:60-84 peptide:65-84
checksum	5F8DCA23D19D29F7
comment	FUNCTION Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).FUNCTION Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11034317, PubMed:11113131).SUBUNIT Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination.SUBCELLULAR LOCATION Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood (PubMed:11034317). Expressed by hepatocytes (PubMed:15124018).INDUCTION Expression in hepatocytes is induced by LPS stimulus and the induction is mediated by IL6 (PubMed:15124018). Expression is inhibited in presence of TNF (PubMed:15124018).MASS SPECTROMETRY The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the hepcidin family.ONLINE INFORMATION Hepcidin entry
description	recommendedName: fullName evidence="15"Hepcidin alternativeName: Liver-expressed antimicrobial peptide 1 shortName: LEAP-1 alternativeName: Putative liver tumor regressor shortName: PLTR component recommendedName: Hepcidin-25 shortName: Hepc25 /component component recommendedName: Hepcidin-20 shortName: Hepc20 /component
geneName	HAMP HEPC LEAP1 UNQ487/PRO1003
identifier	P81172
isSequenceChanged	FALSE
keyword	3D-structure Antibiotic Antimicrobial Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Fungicide Hormone Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	HAMP
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:5660095] ENSEMBL:ENSG00000105697 HAMP [Homo sapiens]
secondaryIdentifier	HEPC_HUMAN Q1HE14 Q9BY68
sequenceLength	84
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:5660387] HAMP [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5691206] HAMP(60-84) [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P81172 HAMP (56458)