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Details on Person UniProt:Q96DB2 HDAC11
| Class:Id | ReferenceGeneProduct:56406 |
|---|---|
| _chainChangeLog | chain:1-347 added on Fri February 6 2015 |
| _displayName | UniProt:Q96DB2 HDAC11 |
| _timestamp | 2025-02-21 19:07:28 |
| chain | chain:1-347 |
| checksum | 0D976CAF6EAC7A15 |
| comment | FUNCTION Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.CATALYTIC ACTIVITY N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetateSUBUNIT Interacts with HDAC6.INTERACTION Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.MISCELLANEOUS Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.SIMILARITY Belongs to the histone deacetylase family.SEQUENCE CAUTION Truncated C-terminus. |
| description | recommendedName: Histone deacetylase 11 shortName: HD11 ecNumber evidence="2"3.5.1.98 |
| geneName | HDAC11 |
| identifier | Q96DB2 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chromatin regulator Hydrolase Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | HDAC11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997197] ENSEMBL:ENSG00000163517 HDAC11 [Homo sapiens] |
| secondaryIdentifier | HDA11_HUMAN B4DDK1 Q9H6I7 Q9H6X3 Q9NTC9 |
| sequenceLength | 347 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973811] UniProt:Q96DB2-1 HDAC11 [Homo sapiens] [ReferenceIsoform:8973812] UniProt:Q96DB2-2 HDAC11 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:351590] HDAC11 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96DB2 HDAC11 (56406)
