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Details on Person WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)

Class:Id	Reaction:5638157
_displayName	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)
_doRelease	TRUE
_timestamp	2016-07-04 13:07:30
authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:8878383] histone H3 methyltransferase activity of WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5638142] Jupe, Steve, 2014-11-13
edited	[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
input	[CandidateSet:5638139] MeK37-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3301907] The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate [LiteratureReference:5173306] NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [LiteratureReference:5638155] Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex [LiteratureReference:5638166] The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation [LiteratureReference:8876769] Trithorax-group protein ASH1 methylates histone H3 lysine 36
modified	[InstanceEdit:5638173] Jupe, Steve, 2014-11-13 [InstanceEdit:5638320] Jupe, Steve, 2014-11-13 [InstanceEdit:5643672] Jupe, Steve, 2014-11-17 [InstanceEdit:5643684] Jupe, Steve, 2014-11-17 [InstanceEdit:5651717] Jupe, Steve, 2014-11-24 [InstanceEdit:5674563] Jupe, Steve, 2015-02-13 [InstanceEdit:5676065] Jupe, Steve, 2015-02-19 [InstanceEdit:8878382] Jupe, Steve, 2016-07-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate MeK37-histone H3 (H3K36) WHSC1, NSD1, SMYD2, ASH1L methylate MeK37-histone H3
output	[CandidateSet:5638169] Me2K37-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2015-03-15
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645099] R-HSA-5638157.3
summation	[Summation:5638331] Methylation of histone H3 lysine-37 (H3K36) is tightly assoc...
systematicName	WHSC1, NSD1, SMYD2 transfer CH3 from AdoMet to MeK37-histone H3
(hasEvent)	[Pathway:3214841] PKMTs methylate histone lysines [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782698] Update Tracker - [Reaction:5638157] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) - v58:[addLiteratureReference, add_removeCatalystActivity, modifyText] [_UpdateTracker:9785277] Update Tracker - [Reaction:5638157] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) - v52:[modifyText]
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No pathways have been reviewed or authored by WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) (5638157)