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Details on Person The RAB8 guanine nucleotide exchange factor RAB3IP/RABIN8 is...
| Class:Id | Summation:5637931 |
|---|---|
| _displayName | The RAB8 guanine nucleotide exchange factor RAB3IP/RABIN8 is... |
| _timestamp | 2016-10-20 14:54:31 |
| created | [InstanceEdit:5637932] Rothfels, Karen, 2014-11-13 |
| modified | [InstanceEdit:8942759] Rothfels, Karen, 2016-10-20 |
| text | The RAB8 guanine nucleotide exchange factor RAB3IP/RABIN8 is recruited to vesicles through interaction with membrane-tethered RAB11:GTP (Westlake et al, 2011; Knodler et al, 2010). Recruitment of RAB3IP may also depend on the TRAPPCII complex, a multiprotein complex with roles in vesicular trafficking (Westlake et al, 2011; reviewed in Sacher et al, 2008). RAB3IP is required for RAB8A to localize to the cilium, and depletion of RAB3IP compromises cilia formation (Nachury et al, 2007; Loktev et al, 2008). GTP-bound RAB8A may promote ciliogenesis by promoting the traffic of post-Golgi vesicles to the base of the cilium (Nachury et al, 2007; Westlake et al, 2011; Feng et al, 2012; reviewed in Reiter et al, 2012) |
| (summation) | [Reaction:5638014] RAB11A:GTP-containing Golgi vesicles recruit RAB3IP [Homo sapiens] |
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No pathways have been reviewed or authored by The RAB8 guanine nucleotide exchange factor RAB3IP/RABIN8 is... (5637931)
