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Details on Person SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)

Class:Id	Reaction:5637808
_displayName	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
_doRelease	TRUE
_timestamp	2018-11-29 15:12:13
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:5637804] guanyl-nucleotide exchange factor activity of p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5637809] Orlic-Milacic, Marija, 2014-11-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9630169] gain_of_function of p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5637789] Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor
modified	[InstanceEdit:9630170] Orlic-Milacic, Marija, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
normalReaction	[Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) [Homo sapiens]
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:5637798] Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex [Homo sapiens] [Reaction:5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644454] R-HSA-5637808.3
summation	[Summation:5637774] SOS1 is the guanine nucleotide exchange factor (GEF) for RAS...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
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No pathways have been reviewed or authored by SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (5637808)