Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII

Class:Id	Reaction:5637801
_displayName	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
_doRelease	TRUE
_timestamp	2018-02-20 14:50:49
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:9037678] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5637799] Orlic-Milacic, Marija, 2014-11-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9037676] gain_of_function of p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane]
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5637791] EGFRvIII-mediated radioresistance through a strong cytoprotective response [LiteratureReference:5637781] Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
modified	[InstanceEdit:9037679] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
normalReaction	[Reaction:177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Homo sapiens]
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:5637765] Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII [Homo sapiens] [Reaction:5637764] Binding of GRB2:GAB1 complex to p-EGFRvIII mutant [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6781723] R-HSA-5637801.3
summation	[Summation:5637773] The kinase activity of PI3K mediates the phosphorylation of ...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779754] Update Tracker - [Reaction:5637801] Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII - v64:[add_removeCatalystActivity]
[Change default viewing format]

No pathways have been reviewed or authored by Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (5637801)