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Details on Person Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant

Class:Id	Reaction:5637800
_displayName	Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant
_doRelease	TRUE
_timestamp	2018-11-29 15:09:51
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5637799] Orlic-Milacic, Marija, 2014-11-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9630163] gain_of_function of p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane]
input	[Complex:5637706] p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2008120] EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes [LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element
modified	[InstanceEdit:9630164] Orlic-Milacic, Marija, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant
normalReaction	[Reaction:212713] Active PLC-gamma1 dissociates from EGFR [Homo sapiens]
output	[EntityWithAccessionedSequence:167679] p-4Y-PLCG1 [plasma membrane] [Homo sapiens] [Complex:1248654] p-5Y-EGFRvIII mutant dimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant [Homo sapiens] [Reaction:5637792] PLC-gamma 1 binds to p-EGFRvIII mutant [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644268] R-HSA-5637800.3
summation	[Summation:5637779] Once phosphorylated, PLC-gamma 1 is expected to dissociate f...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
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No pathways have been reviewed or authored by Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (5637800)