Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex

Class:Id	Reaction:5637798
_displayName	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex
_doRelease	TRUE
_timestamp	2018-11-29 15:07:50
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5637797] Orlic-Milacic, Marija, 2014-11-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9630158] gain_of_function of p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane]
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [Complex:5637703] p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:9630160] Orlic-Milacic, Marija, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex
normalReaction	[Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Homo sapiens]
output	[Complex:5637704] p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII [Homo sapiens] [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644616] R-HSA-5637798.3
summation	[Summation:5637777] Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphoryl...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
(precedingEvent)	[Reaction:5637808] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (5637798)